The blood-brain barrier is a management system in which the capillaries in the brain are encapsulated by a double layer of membrane produced by the endothelial cells in the brain, preventing the brain from touching the toxic substances in the blood night. This management system also allows some key chemicals, such as glucose water according to the key molecular biology practical significance to maintain all the normal physiology of the central nervous system software, but one of the defects of the blood-brain barrier is that it can block most of the drugs, especially chemotherapy drugs into the brain smoothly to treat brain cancer and other diseases. Not long ago, Australian scientists announced that they could rely on a technology called "ultrasonic screwdriver" to raise the blood-brain barrier, and what is even more incredible is that this technology also ensures that the blood-brain barrier remains intact after treatment.

Recently, there has been a major advancement in the research work related to raising the blood-brain barrier, in which doctors and experts in Paris, France, embedded high-frequency ultrasound (a sound frequency that exceeds the range of our English hearing) transmitters into the brains of four patients suffering from malignant brain cancer (collagen fibroblastoma), and then injected "micro-vapor bubbles" into the patients' bodies. These vapor bubbles circulate throughout the patient's body, touching the blood-brain barrier, which cannot be penetrated under normal circumstances. After running the high-frequency ultrasound transmitter in the patient's brain, the micro-vapor bubbles in the patient's body expand and close at a rate of 20,000 times per second, and this type of vibration and pressure strength makes the endothelial cell gaps in the blood-brain barrier compulsory to open, and chemotherapy drugs can enter the heart and brain vessels according to these gaps to reach the disease and carry out treatment.

Color Doppler Ultrasound System

The research staff showed that this type of blood-brain barrier being raised can only be maintained for 2 minutes or less, and the gaps opened are small enough to ensure that other locations of the brain are not vulnerable to damage from toxic substances.

Although this type of technicality is very reasonable, the stage of embedding ultrasound transmitters into the brain must be improved. Dr. Todd Mainprize and Dr. Kullervo Hynynen of Sunnybrook Hospital in Toronto have improved this technique by eliminating the need to perform brain surgery on the patient. The actual improvement was as follows: chemotherapy drugs were encapsulated in microvesicles and introduced into the blood night. When the research staff examines the site of the malignant tumor based on magnetic resonance imaging (MRI), they immediately turn on the ultrasound transmitter outside the body, and the focused ultrasound beams from the transmitter are immediately effective at the blood-brain barrier, causing the microbubbles to vibrate and open the blood-brain barrier so that the drug can be absorbed smoothly, and the microbubbles can eventually be digested by the lungs. More critically, the patient does not have to carry out all manner of surgical treatment during the entire treatment process. Recently, the research staff applied this technology for the first time in a clinical study, in which 10 middle-aged women with brain tumors were treated. 24 hours after the treatment experiment was completed, the research staff tested a sample of malignant tumors and nearby institutions to see the total number of drugs reaching the disease.

This trial, if proven reasonable and safe, could change the technical nature of brain surgery, and the research staff suggests that Alzheimer's disease is the next overall target for technical ultrasound treatments, which have already been studied at this stage.

Posted by: eleanoref at 07:57 AM | No Comments | Add Comment
Post contains 601 words, total size 4 kb.